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Endocrine Abstracts

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ea0081p352 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effects of an acute metreleptin injection on hepatic lipid metabolism in patients with lipodystrophy

Beghini Marianna , Metz Matthaeus , Wolf Peter , Bastian Magdalena , Hackl Martina , Baumgartner-Parzer Sabina , Kautzky-Willer Alexandra , Trauner Michael , Marculescu Rodrig , Krebs Michael , Harreiter Jurgen , Wabitsch Martin , von Schnurbein Julia , Brandt-Huenemann Stephanie , Stumvoll Michael , Miehle Konstanze , Santini Ferruccio , Ceccarini Giovanni , Magno Silvia , Pelosini Caterina , Krssak Martin , Pfleger Lorenz , Stangl Herbert , Furnsinn Clemens , Scherer Thomas

Objective: Treatment with metreleptin ameliorates hepatic steatosis in patients with lipodystrophy. The anti-steatotic effect of metreleptin is partially independent of its anorexic action, which suggests a direct effect of metreleptin on hepatic lipid metabolism. However, this mechanism is unknown. Based on previous findings in rodents, we hypothesized that metreleptin reduces hepatic lipid content by stimulating very-low density lipoprotein triglyceride (VLDL1-TG) secretion,...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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